In one sequence, players are directed to use various instruments and means (e.g., pipe wrench, tooth removal, electrocution) to extract information from a character the sequence is intense and prolonged, and involves some player interaction (i.e., responding to on-screen prompts). Blood-splatter effects occur frequently, and the game contains rare depictions of dismemberment. Players mostly use pistols, machine guns, sniper rifles, and explosives to kill various enemies (e.g., rival gang members) players also have the ability to attack/kill non-adversary civilians, though this may negatively affect players' progress as a penalty system triggers a broad police search. Players can switch between each character to follow his storyline, completing missions which often include criminal activities (e.g., stealing cars, executing heists, assassinating targets).
In this open-world action game, players assume the roles of three criminals whose storylines intersect within the fictional city of Los Santos.